2017

    Curcumin: A Review of Its Effects on Human Health

    Hewlings SJ, Kalman DS

    Published in Foods

    Abstract

    Comprehensive review of curcumin's health effects including anti-inflammatory, antioxidant, and potential disease prevention properties.

    Methodology

    Narrative review of human clinical studies of curcumin and curcuminoid formulations.

    Key Findings

    Review of curcumin trials reports anti-inflammatory and antioxidant effects with signals of benefit in osteoarthritis, metabolic syndrome, hyperlipidaemia, anxiety and exercise-induced muscle soreness. Native curcumin has very poor oral bioavailability; piperine or lipid/phytosome formulations raise absorption substantially.

    Conclusions

    Curcumin has plausible benefit for inflammatory and joint conditions when a bioavailability-enhanced formulation is used; unformulated turmeric powder is unlikely to deliver therapeutic blood levels.

    Limitations

    Narrative review without systematic search or bias appraisal; underlying trials are short, small and often industry-funded, and curcumin is a known assay-interference compound in preclinical work.

    Supplements Studied

    Curcumin shows anti-inflammatory and antioxidant activity with bioavailability limiting clinical effect

    Curcumin
    Compound

    Review of curcumin trials reports anti-inflammatory and antioxidant effects with signals of benefit in osteoarthritis, metabolic syndrome, hyperlipidaemia, anxiety and exercise-induced muscle soreness. Native curcumin has very poor oral bioavailability; piperine or lipid/phytosome formulations raise absorption substantially.

    Outcomes Measured

    Curcumin shows antioxidant and anti-inflammatory activity across human studies

    Related Health Concerns

    Study Details

    Year:2017
    Quality Score:4/10

    Disclosures

    Funding

    Authors disclosed consulting relationships with supplement industry sponsors

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.