Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study
Hidese S, Ota M, Wakabayashi C, Noda T, Ozawa H, Okubo T, Kunugi H
Published in Acta Neuropsychiatrica
Methodology
Eight-week open-label study of L-theanine 250 mg/day added to ongoing medication in patients with major depressive disorder, assessing depression, anxiety, sleep and cognition.
Key Findings
Depressive symptoms, anxiety-trait scores, sleep disturbance and cognitive performance all improved from baseline during L-theanine administration.
Conclusions
L-theanine may be a useful adjunct in major depression, pending controlled trials.
Limitations
Open-label with no placebo group; small sample; concurrent medication confounds interpretation.
Supplements Studied
Depressive symptoms, anxiety-trait scores, sleep disturbance and cognitive performance improved during L-theanine administration.
Related Health Concerns
Study Details
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Disclosures
Funding
Japanese academic funding
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.