Magnesium in Prevention and Therapy
Gröber U, Schmidt J, Kisters K
Published in Nutrients
Abstract
Comprehensive review of magnesium's therapeutic applications, including its role in sleep regulation, stress response, and neuromuscular function.
Methodology
Narrative review of magnesium biochemistry, assessment methods, dosing forms and clinical trial evidence.
Key Findings
Review of magnesium physiology and therapeutics: deficiency is common and poorly detected by serum levels, and supplementation is used in migraine prophylaxis, eclampsia, arrhythmia, asthma and insulin resistance. Organic salts (citrate, glycinate) show better bioavailability than magnesium oxide.
Conclusions
Magnesium repletion is well supported for defined clinical indications and low-risk at ordinary doses, but claims across the wider range of conditions rest on small or heterogeneous trials.
Limitations
Narrative review without systematic search or risk-of-bias appraisal; conflates strong indications (eclampsia) with speculative ones (sleep, stress).
Supplements Studied
Review of magnesium physiology and therapeutics: deficiency is common and poorly detected by serum levels, and supplementation is used in migraine prophylaxis, eclampsia, arrhythmia, asthma and insulin resistance. Organic salts (citrate, glycinate) show better bioavailability than magnesium oxide.
Outcomes Measured
Magnesium plays a crucial role in sleep regulation through effects on GABA receptors and melatonin production. Deficiency is associated with poor sleep quality.
Related Health Concerns
Study Details
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Disclosures
Funding
No external funding reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.