Role of vitamin C and E supplementation on IL-6 in response to training
Yfanti C, Fischer CP, Nielsen S, Akerström T, Nielsen AR, Veskoukis AS, Kouretas D, Lykkesfeldt J, Pilegaard H, Pedersen BK
Published in Journal of Applied Physiology
Methodology
Randomized placebo-controlled trial: young healthy men allocated to vitamin C and E or placebo, with 1-h cycling trials at 65% maximal power before and after 12 weeks of progressive endurance training; plasma and muscle IL-6 measured
Key Findings
The acute exercise-induced IL-6 response was attenuated by training in placebo but not in the vitamin group, with no clear difference between groups (group x training P = 0.13); oxidative stress markers were overall higher in the vitamin group.
Conclusions
Vitamin C and E supplementation shows no clear additive anti-inflammatory benefit when combined with endurance training.
Limitations
Very small sample (n=21), healthy young men only, mechanistic markers rather than performance outcomes.
Supplements Studied
Although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.
Although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.
Outcomes Measured
Although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.
Study Details
Access Study
Disclosures
Funding
Copenhagen Muscle Research Centre / University of Copenhagen
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