Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial
Schmid B, Ludtke R, Selbmann HK, Kotter I, Tschirdewahn B, Schaffner W, Heide L
Published in Phytotherapy Research
Methodology
Randomised double-blind placebo-controlled trial of willow bark extract standardised to 240 mg salicin daily for 2 weeks in painful osteoarthritis of hip or knee.
Key Findings
WOMAC pain scores fell 14% with willow bark versus 2% with placebo, a statistically significant difference, with good tolerability.
Conclusions
Standardised willow bark extract produced a modest short-term analgesic effect in osteoarthritis.
Limitations
Very short two-week treatment period; small effect size; single centre.
Supplements Studied
WOMAC pain scores fell 14% with willow bark versus 2% with placebo.
Outcomes Measured
WOMAC pain scores fell 14% with willow bark versus 2% with placebo.
Willow bark produced a modest short-term reduction in osteoarthritis joint pain.
Related Health Concerns
Study Details
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