Serum Ascorbic Acid and Gallbladder Disease Prevalence Among US Adults: The Third National Health and Nutrition Examination Survey (NHANES III)
Simon JA, Hudes ES
Published in Archives of Internal Medicine
Methodology
Cross-sectional analysis of NHANES III data on serum ascorbic acid and gallbladder disease prevalence in a nationally representative US adult sample
Key Findings
Higher serum vitamin C levels were inversely associated with gallbladder disease prevalence, particularly in women, with a dose-response gradient across quintiles
Conclusions
Serum ascorbic acid is inversely and independently associated with gallbladder disease prevalence
Limitations
Cross-sectional design precludes causal inference; single serum measurement; residual confounding
Supplements Studied
To examine the relationship of ascorbic acid, an antioxidant nutrient involved in cholesterol catabolism, to gallbladder disease, we analyzed data collected from a probability sample of US adults.
Related Health Concerns
Study Details
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Disclosures
Funding
US Public Health Service / National Center for Health Statistics
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