The impact of probiotics on Helicobacter pylori eradication with bismuth quadruple therapy: A systematic review and meta-analysis.
Liu YH, Zhang J, Li DH, Zhang YP
Published in International Journal of Antimicrobial Agents
Methodology
Systematic review and meta-analysis of 19 RCTs comparing probiotic-supplemented bismuth quadruple therapy with standard bismuth quadruple therapy
Key Findings
Probiotic-supplemented bismuth quadruple therapy improved eradication rates (OR 1.49, 95% CI 1.20-1.85; I2 = 0%); both Saccharomyces boulardii (OR 1.62) and multi-strain probiotics (OR 1.66) were effective.
Conclusions
Adjunctive probiotics modestly improve H. pylori eradication with bismuth quadruple therapy and reduce adverse events.
Limitations
Heterogeneous probiotic strains, doses and durations across trials; mostly regional trial populations.
Supplements Studied
PBQT significantly improved H. pylori eradication rates compared to BQT alone (pooled odds ratio [OR] = 1.49, 95% confidence interval [CI] 1.20-1.85; P = 0.0004), with low heterogeneity (I² = 0%).
PBQT significantly improved H. pylori eradication rates compared to BQT alone (pooled odds ratio [OR] = 1.49, 95% confidence interval [CI] 1.20-1.85; P = 0.0004), with low heterogeneity (I² = 0%).
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.