Impact of micronutrient deficiency & malnutrition in systemic sclerosis: Cohort study and literature review
Dupont R, Longue M, Galinier A, Pugnet G
Published in Autoimmunity Reviews
Methodology
Single-centre cohort study measuring serum micronutrient status and nutritional indices in patients with systemic sclerosis, combined with a narrative literature review of published deficiency prevalence.
Key Findings
A cohort study with accompanying literature review found micronutrient deficiencies were common in systemic sclerosis - most frequently vitamin D, selenium, zinc, vitamin B9/B12 and iron - and clustered with malnutrition, gastrointestinal involvement and worse disease severity scores.
Conclusions
Se testing should be considered as soon as cardiac involvement is suspected. VitC testing should be considered in malnourished SSc patients, especially if skin involvement is extensive.
Limitations
Observational cohort with modest and incompletely reported sample; single-centre referral population prone to severity bias; deficiency thresholds varied across the reviewed literature; no interventional data showing that repletion changes disease outcomes.
Supplements Studied
Se testing should be considered as soon as cardiac involvement is suspected. VitC testing should be considered in malnourished SSc patients, especially if skin involvement is extensive.
Se testing should be considered as soon as cardiac involvement is suspected. VitC testing should be considered in malnourished SSc patients, especially if skin involvement is extensive.
A cohort study with accompanying literature review found micronutrient deficiencies were common in systemic sclerosis - most frequently vitamin D, selenium, zinc, vitamin B9/B12 and iron - and clustered with malnutrition, gastrointestinal involvement and worse disease severity scores.
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Academic hospital institutional funding
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.