Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial
Snitz BE, O'Meara ES, Carlson MC, Arnold AM, Ives DG, Rapp SR
Published in JAMA
Methodology
Double-blind placebo-controlled trial (Ginkgo Evaluation of Memory study), 120 mg EGb761 twice daily vs placebo, median 6.1 years follow-up
Key Findings
Ginkgo biloba did not slow the rate of decline in memory, attention, visuospatial ability, language or executive function compared with placebo.
Conclusions
Standardised ginkgo extract does not slow age-related cognitive decline in community-dwelling older adults.
Limitations
Participants largely cognitively normal at baseline; adherence declined over the long follow-up.
Supplements Studied
Compared with placebo, the use of G. biloba, 120 mg twice daily, did not result in less cognitive decline in older adults with normal cognition or with mild cognitive impairment.
Outcomes Measured
Ginkgo biloba, 120 mg twice daily, did not result in less cognitive decline over a median of 6.1 years of follow-up.
Ginkgo biloba did not slow the rate of decline in memory, attention, visuospatial ability, language or executive function compared with placebo.
Related Health Concerns
Study Details
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