Nicotinamide Mononucleotide (NMN) Supplementation Ameliorates the Impact of Maternal Obesity in Mice
Uddin GM, Youngson NA, Sinclair DA, Morris MJ
Published in Nutrients
Abstract
This study demonstrates that NMN supplementation can ameliorate metabolic dysfunction associated with maternal obesity through NAD+ restoration. Results showed improved glucose tolerance, reduced oxidative stress, and enhanced mitochondrial function in offspring.
Methodology
Preclinical mouse study administering nicotinamide mononucleotide to obese dams and/or offspring, measuring glucose tolerance, hepatic NAD+ levels, oxidative stress markers and mitochondrial function.
Key Findings
NMN restored NAD+ levels and improved glucose tolerance in offspring of obese dams, reduced markers of oxidative stress, and improved indicators of mitochondrial function in liver tissue. Effects varied by whether NMN was given to the mother, the offspring, or both.
Conclusions
NMN can partially reverse metabolic programming caused by maternal obesity in mice by restoring NAD+ availability, supporting further mechanistic investigation.
Limitations
Mouse model only; no human evidence. NMN doses used in mice greatly exceed typical human supplement exposure on a body-weight-adjusted basis, and human NAD+ repletion trials have not demonstrated comparable metabolic benefits.
Supplements Studied
NMN restored NAD+ levels and improved glucose tolerance in offspring of obese dams, reduced markers of oxidative stress, and improved indicators of mitochondrial function in liver tissue. Effects varied by whether NMN was given to the mother, the offspring, or both.
Outcomes Measured
NMN restored NAD+ levels and improved glucose tolerance in offspring of obese dams, reduced markers of oxidative stress, and improved indicators of mitochondrial function in liver tissue. Effects varied by whether NMN was given to the mother, the offspring, or both.
NMN restored NAD+ levels and improved glucose tolerance in offspring of obese dams, reduced markers of oxidative stress, and improved indicators of mitochondrial function in liver tissue. Effects varied by whether NMN was given to the mother, the offspring, or both.
Related Health Concerns
Study Details
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