Micronized purified flavonoid fraction containing hesperidin and diosmin for haemorrhoidal disease and chronic venous disease: systematic review and meta-analysis
Perera N, Liolitsa D, Iype S, Croxford A, Yassin M, Lang P, Ukaegbu O, van Issum C
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane review of randomised trials of phlebotonics including hesperidin-diosmin fractions for haemorrhoids and venous disease
Key Findings
Flavonoid preparations reduced bleeding and persisting symptoms in haemorrhoidal disease, but trials were of low methodological quality with possible publication bias.
Conclusions
Hesperidin-containing flavonoid fractions likely help haemorrhoidal symptoms, on low-certainty evidence.
Limitations
Poor trial quality; mostly industry-sponsored studies.
Supplements Studied
Flavonoid preparations reduced bleeding and persisting symptoms in haemorrhoidal disease, but trials were of low methodological quality.
Numerous trials assessing the effect of phlebotonics in treating the symptoms and signs of haemorrhoidal disease suggest that there is a potential benefit.
Related Health Concerns
Study Details
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