Artichoke and cardiometabolic health: A systematic and meta-analytic synthesis of current evidence
Jafari A, Karimi MA, Mahmoudinezhad M, Razavi F, Mardani H, Musazadeh V
Published in Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Methodology
Systematic review and meta-analysis of RCTs on artichoke supplementation and cardiometabolic markers, databases searched to September 2024
Key Findings
Reductions in BMI, systolic BP -2.49 mmHg, diastolic BP -1.53 mmHg, total cholesterol -12.29 mg/dL, LDL-C -10.31 mg/dL, triglycerides -12.85 mg/dL, insulin -1.83 mU/L, HOMA-IR -0.92 and ALT -8.47 U/L. HDL-C, fasting glucose and HbA1c unaffected.
Conclusions
Artichoke supplementation improves several lipid, blood pressure, insulin-resistance and liver markers, but not HDL, fasting glucose or HbA1c.
Limitations
Heterogeneity across extract types and doses; several pooled estimates rest on few trials.
Supplements Studied
Significant lipid profile improvements were observed in total cholesterol, low-density lipoprotein cholesterol, and triglycerides, with no significant effect on high-density lipoprotein cholesterol
Outcomes Measured
Blood pressure outcomes revealed significant reductions in both systolic and diastolic pressures
triglycerides (WMD = -12.85 mg/dL, 95 % CI: 24.77 to -0.93)
Significant lipid profile improvements were observed in total cholesterol, low-density lipoprotein cholesterol, and triglycerides
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.