Effects of Vitamin D Supplementation on Cognitive Function in Older Adults: A GRADE Methodology-Assessed Systematic Review and Meta-Analysis of Randomized Clinical Trials
Behrouzi R, et al.
Published in Nutrition Reviews
Methodology
GRADE-assessed systematic review and meta-analysis of randomized clinical trials of vitamin D supplementation in older adults, pooling standardized mean differences across cognitive domains.
Key Findings
Pooled randomized trials showed no significant benefit of vitamin D supplementation on global cognition, executive function, attention or perceptual speed in older adults; GRADE certainty was low to moderate.
Conclusions
No significant enhancement was found in executive function, attention, or perceptual speed domains.
Limitations
Heterogeneous doses, durations and cognitive batteries; most participants vitamin D-replete at baseline; few trials in cognitively impaired populations.
Supplements Studied
While no significant enhancement in the domains of executive function, attention, and perceptual speed was found.
Outcomes Measured
Pooled randomized trials showed no significant benefit of vitamin D supplementation on global cognition, executive function, attention or perceptual speed in older adults; GRADE certainty was low to moderate.
Pooled randomized trials showed no significant benefit of vitamin D supplementation on global cognition, executive function, attention or perceptual speed in older adults; GRADE certainty was low to moderate.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.