Effectiveness of Volbella (VYC-15L) for Infraorbital Hollowing: Patient-Reported Outcomes From a Prospective, Multicenter, Single-Blind, Randomized, Controlled Study

Fabi S

Published in Aesthetic Surgery Journal

Methodology

Prospective, multicentre, single-blind randomized controlled study of VYC-15L injection for infraorbital hollowing with validated patient-reported outcome instruments assessed to 12 months.

Key Findings

Hyaluronic acid filler (VYC-15L) for infraorbital hollowing produced sustained patient-reported improvement in under-eye appearance and reduced bother from dark circles and tear-trough hollowing through 12 months versus untreated control.

Conclusions

Hyaluronic acid filler for infraorbital hollowing reduced bother from under-eye dark circles through 12 months.

Limitations

Single-blind design with no sham injection, patient-reported subjective endpoints, industry sponsorship, and results specific to filler rather than any topical or supplemental intervention.