Role of oral hyaluronic acid for joint health: insights from rat models and clinical trials
Chen Y, Liu H, Sun Q, Zhao L
Published in Frontiers in Nutrition
Methodology
Review of animal and human evidence on oral hyaluronic acid absorption and joint outcomes
Key Findings
Ingested hyaluronic acid is degraded and absorbed as fragments by gut microbiota, with clinical joint effects that are small, inconsistent and often derived from underpowered trials.
Conclusions
Oral hyaluronic acid for joints has plausible but weakly evidenced benefit.
Limitations
Mixed animal and human evidence; heterogeneous molecular weights.
Supplements Studied
Clinical joint effects are small, inconsistent and often derived from underpowered trials.
Outcomes Measured
Clinical joint effects are small, inconsistent and often derived from underpowered trials.
Related Health Concerns
Study Details
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