Homocysteine Reduction
Lower cardiovascular risk marker levels.
TL;DR
B12, folate and B6 lower homocysteine reliably. The catch is that trials lowering it have not consistently reduced cardiovascular events, though stroke risk may fall modestly.
Why It Matters
Elevated homocysteine is associated with cardiovascular disease, cognitive decline and venous thrombosis, and markedly elevated levels can indicate B12 deficiency or an inherited metabolic disorder needing investigation.
How to Measure
Biomarkers
Optimization Protocol
Check B12 and folate status first, since deficiency is the most common correctable cause. Supplement B12 at 500-1000 mcg daily if low, folate at 400-800 mcg, and B6 at 25-50 mg. Betaine at 3 g daily lowers homocysteine independently. Reduce alcohol and stop smoking, both of which raise levels.
Supporting Supplements
Folate (Vitamin B9)
Folate reliably lowers homocysteine, typically by 20-25 percent, and is the single most effective nutrient for this marker.
N-Acetyl Cysteine (NAC)
NAC lowers homocysteine modestly in some trials, likely by displacing it from protein binding.
Betaine (TMG)
Betaine lowers homocysteine independently of folate, especially post-methionine load.
Supporting Research
Frequently Asked Questions
Typical Timeframe
6-12 weeks
Research Summary
My Notes
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.