Pantethine, a derivative of vitamin B5, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects
Rumberger JA, Napolitano J, Azumano I, Kamiya T, Evans M
Published in Nutrition Research
Methodology
Randomised placebo-controlled trial of pantethine 600-900 mg daily for 16 weeks with lipid subfraction analysis.
Key Findings
LDL cholesterol fell about 11% at 16 weeks with favourable shifts in LDL particle distribution and no safety signals.
Conclusions
Pantethine modestly improves LDL metabolism in low- to moderate-risk adults.
Limitations
Small sample, supplement-manufacturer funding, surrogate endpoints only.
Supplements Studied
LDL cholesterol fell approximately 11% after 16 weeks of pantethine supplementation.
Outcomes Measured
LDL cholesterol fell about 11% at 16 weeks with favourable shifts in LDL particle distribution and no safety signals.
Related Health Concerns
Study Details
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