Outcome
    Strong Evidence
    Effectiveness 4/5

    Iron for Hair Follicle Stimulation

    Iron deficiency is a common and reversible cause of diffuse hair shedding, and correcting low ferritin restores normal follicle cycling.

    Overview

    Verdict

    Strong yes

    Evidence supports correcting documented iron deficiency in hair loss; there is no good evidence that iron or routine micronutrient supplementation stimulates hair growth in people without deficiency.

    How It Works

    Downstream effects

    Ribonucleotide reductase requires iron for DNA synthesis
    Hair matrix cells are among the fastest dividing in the body
    Iron shortage deprioritises hair before it affects haemoglobin
    Follicles shift prematurely from anagen to telogen
    Shedding appears 2-3 months after the trigger
    Regrowth follows the follicle cycle, not the blood test

    Dosing & Protocol

    Doses used clinically

    SituationDoseScheduleNotes
    Confirmed iron deficiency65 mg elemental ironOnce daily or alternate daysAlternate-day dosing improves absorption by lowering hepcidin
    Ferrous sulfate tablet325 mg saltProvides about 65 mg elemental ironThe standard and cheapest preparation
    Poor toleranceFerrous bisglycinate 25-30 mg elementalOnce dailyGentler on the gut, often adequate for mild deficiency
    No documented deficiencyNone-Iron does not stimulate hair growth in replete individuals and risks overload

    Take with vitamin C or orange juice to improve absorption. Do not supplement iron without a ferritin and full blood count result.

    Simple protocol

    1. 1

      Get tested before anything else

      Ferritin plus a full blood count. Iron supplementation without documented deficiency is not supported and is not risk free.

    2. 2

      Find out why iron is low

      Heavy periods, poor intake, coeliac disease and gastrointestinal blood loss all need addressing at source.

    3. 3

      Take 65 mg elemental iron on alternate days· 3 months, then retest

      Alternate-day dosing absorbs better than daily dosing and is gentler.

    4. 4

      Take it with vitamin C, away from tea and calcium

      Tea, coffee, calcium and antacids all substantially reduce absorption.

    5. 5

      Expect the timeline to be slow

      Shedding settles first, visible density follows over 6-12 months as follicles re-enter anagen.

    6. 6

      See a clinician if hair loss continues

      Thyroid disease, androgenetic alopecia and scarring alopecias need different treatment entirely.

    Evidence

    Studies linked to this pairing.

    The Role of Vitamins and Minerals in Hair Loss: A Review

    Score: 6/10
    2019
    systematic_review

    Almohanna HM, Ahmed AA, Tsatalis JP +1 more

    Deficiency of such micronutrients may represent a modifiable risk factor associated with the development, prevention, and treatment of alopecia.

    View source
    Supported use
    Correcting documented iron deficiency
    Not supported
    Routine supplementation in people without deficiency
    Biotin
    No good evidence for hair growth without deficiency
    Marker to test
    Ferritin, alongside a full blood count
    Time to visible change
    Typically 6-12 months, following the follicle cycle
    Main limitation
    Optimal ferritin threshold for hair regrowth is debated and not firmly established

    Safety

    Do not take iron for hair loss without a blood test

    Iron helps hair only when deficiency is documented. In replete people it does not stimulate growth and contributes to iron overload, which is dangerous in haemochromatosis.

    Interactions & Conflicts

    Interactions and cautions

    Interacts withSeverityMechanismAction
    Haemochromatosis or iron overload
    high
    Further accumulation of iron in tissuesAvoid entirely
    Levothyroxine
    high
    Iron binds thyroxine and reduces absorptionSeparate by at least 4 hours
    Tetracycline and quinolone antibiotics
    high
    Chelation reduces absorption of bothSeparate by at least 2-4 hours
    Proton pump inhibitors and antacids
    moderate
    Reduced gastric acid impairs iron absorptionTake iron with vitamin C and discuss with a clinician
    Tea, coffee and calcium
    moderate
    Polyphenols and calcium inhibit non-haem iron absorptionSeparate by an hour either side
    Unexplained deficiency in men or postmenopausal women
    high
    May indicate gastrointestinal blood lossSeek medical assessment before self-treating

    References

    1. Almohanna HM et al. The role of vitamins and minerals in hair loss: a review. Dermatology and Therapy (2019)
    2. NIH Office of Dietary Supplements - Iron fact sheet for health professionals
    3. British Association of Dermatologists - Hair loss patient information

    Frequently Asked Questions

    Medical Disclaimer

    The information provided on this website is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any supplement regimen.

    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.