Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children
Hahn S, Kim S, Garner P
Published in Cochrane Database Syst Rev (1), pp. CD002847
Methodology
Cochrane systematic review of randomised trials comparing reduced-osmolarity oral rehydration solution with the older WHO standard solution in children with acute diarrhea; primary outcome was unscheduled intravenous fluid.
Key Findings
In a meta-analysis of 8 trials, reduced-osmolarity solution cut unscheduled intravenous infusions (odds ratio 0.59, 95% CI 0.45 to 0.79) with no heterogeneity. It also reduced stool output and vomiting, with no extra hyponatremia detected.
Conclusions
In children admitted with diarrhea, the lower-sodium, lower-glucose formula works better than the original WHO solution.
Limitations
Compares two oral rehydration formulas rather than oral rehydration against no treatment; hospitalised children, mostly in low-income settings.
Supplements Studied
reduced osmolarity ORS was associated with fewer unscheduled intravenous fluid infusions
Related Health Concerns
Study Details
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