Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial
Spector TD, Calomme MR, Anderson SH
Published in BMC Musculoskeletal Disorders
Methodology
Randomized, double-blind, placebo-controlled 12-month trial of 3-12 mg/day silicon as ch-OSA plus calcium and vitamin D3 in osteopenic women.
Key Findings
Bone formation marker PINP rose significantly in the 6 and 12 mg silicon arms; femoral and lumbar BMD changes did not reach significance.
Conclusions
ch-OSA had a potentially beneficial effect on bone collagen formation, but no significant BMD effect was demonstrated over 12 months.
Limitations
Biomarker rather than fracture or BMD endpoints; industry funded.
Supplements Studied
ch-OSA had a potentially beneficial effect on bone collagen formation, but no significant BMD effect was demonstrated over 12 months.
Bone formation marker PINP rose significantly in the 6 and 12 mg silicon arms; femoral and lumbar BMD changes did not reach significance.
Bone formation marker PINP rose significantly in the 6 and 12 mg silicon arms; femoral and lumbar BMD changes did not reach significance.
Outcomes Measured
Femoral and lumbar BMD changes did not reach significance.
Related Health Concerns
Study Details
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