n-3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease (DREAM)
Asbell PA, Maguire MG, Pistilli M
Published in New England Journal of Medicine
Methodology
Multicentre double-blind RCT of 3000 mg/day EPA+DHA versus olive oil placebo for 12 months in moderate-to-severe dry eye.
Key Findings
No significant difference in symptom score improvement between omega-3 and placebo (change 13.9 vs 12.5 points); signs also unchanged.
Conclusions
High-dose omega-3 did not relieve dry eye symptoms or visual disturbance beyond placebo.
Limitations
Placebo was olive oil, which may not be inert; high adherence population.
Supplements Studied
High-dose omega-3 did not relieve dry eye symptoms beyond placebo.
Outcomes Measured
Omega-3 did not improve dry eye symptoms or signs versus placebo.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.