rct
    2011
    High Quality

    Vitamin E and the Risk of Prostate Cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT) updated follow-up

    Klein EA, Thompson IM, Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, Minasian LM, Ford LG, Parnes HL, Gaziano JM, Karp DD, Lieber MM, Walther PJ, Klotz L, Parsons JK, Chin JL, Darke AK, Lippman SM, Goodman GE, Meyskens FL, Baker LH

    Published in JAMA

    Key Findings

    Extended follow-up showed vitamin E increased prostate cancer risk by 17 percent, while selenium alone conferred no protection.

    Conclusions

    Neither selenium nor vitamin E prevents prostate cancer, and vitamin E may cause harm.

    Limitations

    Post-intervention follow-up; selenium-replete cohort.

    Supplements Studied

    Vitamin E
    Vitamin

    Vitamin E supplementation significantly increased the risk of prostate cancer among healthy men.

    Selenium
    Mineral

    Extended follow-up showed vitamin E increased prostate cancer risk by 17 percent, while selenium alone conferred no protection.

    Related Health Concerns

    Prostate Cancer
    Cancer

    Study Details

    Year:2011
    Sample Size:35,533
    Duration:364 weeks
    Quality Score:10/10

    Access Study

    View on DOIOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.