St John's wort for major depression
Linde K, Berner MM, Kriston L
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane review of 29 randomised trials of Hypericum perforatum extracts versus placebo or standard antidepressants for major depression.
Key Findings
St John's wort was superior to placebo and comparable to standard antidepressants with fewer adverse effects.
Conclusions
St John's wort is effective for mild to moderate depressive episodes including seasonal patterns.
Limitations
Trials from German-speaking countries reported larger effects; interaction risk high.
Supplements Studied
St John's wort was superior to placebo and comparable to standard antidepressants with fewer adverse effects
Outcomes Measured
St John's wort was superior to placebo and comparable to standard antidepressants with fewer adverse effects
St John's wort was superior to placebo and comparable to standard antidepressants
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.