Prolonged effect of calcium supplementation on risk of colorectal adenomas in a randomized trial
Grau MV, Baron JA, Sandler RS, Wallace K, Haile RW
Published in Journal of the National Cancer Institute
Methodology
Post-treatment observational follow-up of the Calcium Polyp Prevention Study, in which participants received 1200 mg/day elemental calcium or placebo for 4 years
Key Findings
The protective effect of calcium on adenoma recurrence persisted for up to five years after supplementation stopped, then attenuated
Conclusions
Calcium supplementation has a durable but not permanent effect on adenoma recurrence
Limitations
Observational follow-up phase, incomplete colonoscopy uptake, adenoma surrogate endpoint
Supplements Studied
930 subjects with a previous colorectal adenoma were randomly assigned ... to receive placebo or 1200 mg of elemental calcium daily for 4 years
Related Health Concerns
Study Details
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Disclosures
Funding
National Cancer Institute
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.