Safety considerations with niacin therapy
Guyton JR, Bays HE
Published in American Journal of Cardiology
Methodology
Review of tolerability and safety data across niacin formulations, including flushing, hepatotoxicity, glucose effects and myopathy risk.
Key Findings
Flushing affects most users of immediate-release niacin; sustained-release formulations carry greater hepatotoxicity risk, and glucose elevation is common in patients with insulin resistance.
Conclusions
Niacin safety is formulation dependent and requires monitoring of liver enzymes and glucose.
Limitations
Narrative safety review without pooled quantitative synthesis.
Supplements Studied
Flushing affects most users of immediate-release niacin and glucose elevation is common in insulin-resistant patients.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.