Psychobiotic Effects on Anxiety Are Modulated by Lifestyle Behaviors: A Randomized Placebo-Controlled Trial on Healthy Adults
Morales-Torres R, Carrasco-Gubernatis C, Grasso-Cladera A, Cosmelli D, Parada FJ
Published in Nutrients
Methodology
Randomised placebo-controlled trial in 135 healthy adults taking L. helveticus R0052 plus B. longum R0175 or placebo for 4 weeks, assessing wellbeing, anxiety, emotional regulation, mindfulness and interoception.
Key Findings
No significant effects of probiotic intake were found in the whole sample; benefits on anxiety, emotional regulation and mindfulness appeared only in the subgroup scoring high on healthy lifestyle behaviours.
Conclusions
This well-powered trial was negative for the primary psychobiotic effects, with any benefit conditional on lifestyle behaviours.
Limitations
Healthy adults with low baseline anxiety; subgroup interaction findings are exploratory; combination product prevents strain attribution.
Supplements Studied
Results showed no significant effects of probiotic intake in whole sample outcomes.
Outcomes Measured
Results showed no significant effects of probiotic intake in whole sample outcomes.
Related Health Concerns
Study Details
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Disclosures
Funding
Academic funding
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.