A randomized controlled trial of a probiotic combination VSL#3 and placebo in irritable bowel syndrome with bloating
Kim HJ, Vazquez Roque MI, Camilleri M, Stephens D, Burton DD, Baxter K
Published in Neurogastroenterology and Motility
Methodology
Parallel-group double-blind RCT; 48 Rome II IBS patients with significant bloating received VSL#3 twice daily or placebo for 4-8 weeks with scintigraphic colonic transit measurement.
Key Findings
VSL#3 reduced flatulence scores versus placebo (29.7 vs 39.5, p = 0.011) but did not improve satisfactory relief of bloating, abdominal pain or stool symptoms.
Conclusions
A multi-strain probiotic reduced flatulence specifically, without broader symptom relief.
Limitations
Small sample; mixed treatment durations; single centre.
Supplements Studied
Treatment with VSL# 3 was associated with reduced flatulence over the entire treatment period (placebo 39.5 +/- 2.6 vs VSL# 3 29.7 +/- 2.6, P = 0.011)
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Academic/institutional
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.