Effect of vitamin D supplementation on various parameters in patients with non-alcoholic fatty liver disease: An updated meta-analysis
Li D, Fu N, Wu H
Published in Clinical and Experimental Hepatology
Methodology
Updated meta-analysis of randomized controlled trials comparing vitamin D with placebo in NAFLD, assessing anthropometric and biochemical indices.
Key Findings
Vitamin D raised 25(OH)D and lowered LDL-C, but produced no significant change in ALT, AST, GGT, triglycerides, glucose or HOMA-IR.
Conclusions
Vitamin D corrects status but does not improve liver enzymes or insulin resistance in NAFLD.
Limitations
Short trial durations; no histologic endpoints; heterogeneous dosing.
Supplements Studied
However, no significant differences were found in terms of triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), c-glutamyltransferase, fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR)
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.