rct
    2024
    High Quality

    Long-Term Effect of Randomization to Calcium and Vitamin D Supplementation on Health in Older Women: Postintervention Follow-up of a Randomized Clinical Trial

    Thomson CA, et al

    Published in Ann Intern Med

    Key Findings

    After more than 20 years, calcium plus vitamin D was associated with reduced cancer mortality but increased cardiovascular mortality, with no effect on all-cause mortality.

    Conclusions

    Any cancer-survival benefit is offset by cardiovascular risk in postmenopausal women.

    Limitations

    Post-hoc long-term follow-up; personal supplement use could not be disentangled.

    Supplements Studied

    Calcium
    Mineral

    Calcium and vitamin D supplements seemed to reduce cancer mortality and increase CVD mortality after more than 20 years of follow-up.

    Vitamin D
    Vitamin

    Calcium and vitamin D supplements seemed to reduce cancer mortality and increase CVD mortality after more than 20 years of follow-up.

    Outcomes Measured

    Cancer Survival Rate

    Calcium and vitamin D supplements seemed to reduce cancer mortality and increase CVD mortality after more than 20 years of follow-up among postmenopausal women.

    Related Health Concerns

    Cancer

    Study Details

    Year:2024
    Sample Size:36,282
    Quality Score:8/10

    Access Study

    View on DOIView on PubMedOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.