Branched-chain amino acid supplementation and muscle protein synthesis in humans: a critical appraisal
Wolfe RR
Published in Journal of the International Society of Sports Nutrition
Methodology
Critical review of human tracer studies measuring the effect of isolated branched-chain amino acids on muscle protein synthesis.
Key Findings
Isolated BCAAs raised protein synthesis only transiently and less than complete protein, because the remaining essential amino acids become limiting.
Conclusions
Complete protein outperforms isolated BCAAs for protein metabolism.
Limitations
Narrative review; small tracer studies.
Supplements Studied
Isolated BCAAs raised protein synthesis only transiently and less than complete protein, because the remaining essential amino acids become limiting.
Outcomes Measured
Isolated BCAAs raised protein synthesis only transiently and less than complete protein, because the remaining essential amino acids become limiting
Branched-chain amino acids alone are insufficient to maximise muscle protein synthesis compared with complete protein.
Isolated BCAAs raised protein synthesis only transiently and less than complete protein, because the remaining essential amino acids become limiting.
Study Details
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