An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study
Lopresti AL, Smith SJ, Malvi H, Kodgule R
Published in Medicine
Methodology
Randomised double-blind placebo-controlled trial of 240 mg/day standardised ashwagandha extract for 60 days in adults with elevated stress.
Key Findings
Ashwagandha reduced Hamilton Anxiety and DASS-21 stress scores and lowered morning cortisol compared with placebo, with increased testosterone in men.
Conclusions
Standardised ashwagandha extract modestly reduces perceived stress and morning cortisol in stressed but otherwise healthy adults.
Limitations
Small sample; 60-day duration; supplement manufacturer involvement; self-reported primary outcomes.
Supplements Studied
Ashwagandha reduced Hamilton Anxiety and DASS-21 stress scores and lowered morning cortisol compared with placebo.
Outcomes Measured
Morning cortisol was significantly lower after 60 days of standardised ashwagandha extract than placebo.
An ashwagandha extract reduced perceived stress and serum cortisol versus placebo in a randomized, double-blind trial
Related Health Concerns
Study Details
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