A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis
Wei W, Zhang LL, Xu JH, Xiao F, Bao CD, Ni LQ
Published in Arthritis Research & Therapy
Methodology
Multicenter, double-blind, randomized, methotrexate-controlled phase III trial of oral chicken type II collagen for 24 weeks in rheumatoid arthritis.
Key Findings
Chicken type II collagen produced ACR20 response rates lower than methotrexate but with significantly fewer adverse events.
Conclusions
Oral chicken type II collagen has modest efficacy in rheumatoid arthritis and is better tolerated than methotrexate.
Limitations
Active comparator rather than placebo, moderate dropout, 24-week duration, single-country population.
Supplements Studied
Chicken type II collagen produced ACR20 response rates lower than methotrexate but with significantly fewer adverse events.
Related Health Concerns
Study Details
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