The Impact of Minerals on Female Fertility: A Systematic Review
Kapper C, Stelzl P, Oppelt P, Ganhör C
Published in Nutrients
Methodology
Systematic review of 39 studies (RCTs, prospective cohort, case-control and observational) on mineral status and supplementation in women planning pregnancy or undergoing assisted reproduction (PROSPERO CRD42024547656)
Key Findings
Selenium, zinc and copper were the minerals most consistently linked with oocyte quality, embryo development, oxidative stress, hormonal regulation and IVF outcomes, but supplementation evidence remains largely observational.
Conclusions
Mineral status plausibly influences several reproductive endpoints, yet interventional evidence is too thin to support routine supplementation beyond correcting deficiency.
Limitations
Mostly observational designs; heterogeneous outcome definitions; confounding by overall diet
Supplements Studied
Outcomes Measured
The analysis revealed that minerals like selenium, zinc, and copper
Study Details
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