meta_analysis
    2009
    High Quality

    A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA treatment effects on quality of life in women with adrenal insufficiency

    Alkatib AA, Cosma M, Elamin MB, Erickson D, Swiglo BA, Erwin PJ, Montori VM

    Published in Journal of Clinical Endocrinology & Metabolism

    Methodology

    Meta-analysis of 10 randomised placebo-controlled trials of DHEA replacement in women with primary or secondary adrenal insufficiency.

    Key Findings

    DHEA produced a small improvement in health-related quality of life and depression scores, with no significant effect on anxiety or sexual wellbeing.

    Conclusions

    DHEA replacement in adrenal insufficiency offers at best small quality-of-life benefits and is not routinely recommended.

    Limitations

    Small trials; short duration; heterogeneous quality-of-life instruments; long-term safety unknown.

    Related Health Concerns

    Study Details

    Year:2009
    Sample Size:1,024
    Duration:24 weeks
    Quality Score:8/10

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