The effect of spermidine on memory performance in older adults at risk for dementia: a randomized controlled trial
Wirth M, Benson G, Schwarz C, Kobe T, Grittner U, Schmitz D, Sigrist SJ, Bohlken J, Stekovic S, Madeo F, Floel A
Published in Cortex
Methodology
Three-month randomized, double-blind, placebo-controlled trial of a spermidine-rich wheat germ extract in older adults with subjective cognitive decline.
Key Findings
Mnemonic discrimination performance improved modestly in the spermidine group compared with placebo.
Conclusions
Short-term spermidine supplementation showed preliminary memory benefits in at-risk older adults.
Limitations
Very small pilot sample; single cognitive domain; short duration.
Supplements Studied
Short-term spermidine supplementation showed preliminary memory benefits in at-risk older adults.
Outcomes Measured
Mnemonic discrimination performance improved modestly in the spermidine group compared with placebo.
Related Health Concerns
Study Details
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