rct
2010
Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowth
Furnari M, Parodi A, Gemignani L, Giannini EG
Published in Alimentary Pharmacology & Therapeutics
Methodology
Randomized trial in glucose breath test-positive SIBO patients comparing rifaximin 1200 mg/day alone versus rifaximin plus partially hydrolysed guar gum 5 g/day for 10 days, with breath testing one month after withdrawal.
Key Findings
Adding partially hydrolysed guar gum to rifaximin improved SIBO eradication rates and symptom scores compared with rifaximin alone.
Conclusions
Soluble fibre supplementation may enhance antibiotic eradication of SIBO.
Limitations
Open-label design; single center; short follow-up.
Related Health Concerns
Study Details
Year:2010
Duration:2 weeks
Quality Score:6/10
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Disclosures
Funding
Not reported
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