Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism
Erkkila AT, Lee JC, Lankinen M, Manninen S, Leung HH
Published in Lipids
Methodology
12-week randomized controlled trial in 79 adults with impaired glucose metabolism (72 analysed) comparing camelina oil (10 g/day ALA), fatty fish, lean fish and control; 12-hour urinary prostanoids and isoprostanes measured by LC-MS/MS.
Key Findings
Plasma ALA rose in the camelina oil group, but urinary prostaglandin F2a, isoprostanes, isofuran and neuroprostane levels were not markedly altered by any diet.
Conclusions
Camelina oil did not meaningfully change urinary markers of oxidative stress despite raising plasma ALA - a null result.
Limitations
Urinary prostanoids are a single oxidative-stress window; 12-week duration; modest per-arm numbers.
Supplements Studied
Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group.
Outcomes Measured
Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism.
Related Health Concerns
Study Details
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Disclosures
Funding
Academic funding
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