Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial
Moon JM, Ratliff KM, Hagele AM, Stecker RA, Mumford PW, Kerksick CM
Published in Nutrients
Methodology
Randomized double-blind crossover pilot trial in 5 healthy men comparing single doses of berberine (500 mg) and dihydroberberine (100 mg and 200 mg) on plasma berberine kinetics and postprandial glucose.
Key Findings
Dihydroberberine produced substantially higher and faster plasma berberine appearance than an equivalent berberine dose; glucose and insulin responses were not significantly different between conditions.
Conclusions
Dihydroberberine markedly improves berberine bioavailability, but this pilot did not demonstrate superior acute glycemic control.
Limitations
Only 5 participants; single acute doses; healthy normoglycemic men; industry-supplied product.
Supplements Studied
Dihydroberberine produced substantially higher and faster plasma berberine appearance than an equivalent berberine dose.
Dihydroberberine produced substantially higher and faster plasma berberine appearance than an equivalent berberine dose; glucose and insulin responses were not significantly different between conditions.
Outcomes Measured
Glucose and insulin responses were not significantly different between conditions.
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.