Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
Lang-Illievich K, Klivinyi C, Rumpold-Seitlinger G, Dorn C, Bornemann-Cimenti H
Published in Nutrients
Methodology
Systematic review and meta-analysis of double-blind randomized controlled trials of oral palmitoylethanolamide in chronic pain
Key Findings
Palmitoylethanolamide significantly reduced pain intensity compared with placebo or active comparators, with a favorable adverse event profile
Conclusions
PEA appears effective in reducing chronic pain intensity with good tolerability
Limitations
Small number of trials, heterogeneous formulations and pain conditions, several industry-linked studies
Supplements Studied
Palmitoylethanolamide significantly reduced pain intensity compared with placebo or active comparators, with a favorable adverse event profile
Outcomes Measured
Palmitoylethanolamide significantly reduced pain intensity compared with placebo or active comparators, with a favorable adverse event profile
Related Health Concerns
Study Details
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