Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China (CSPPT)
Huo Y, Li J, Qin X, Huang Y, Wang X, Gottesman RF
Published in JAMA
Methodology
Randomized double-blind trial of enalapril plus folic acid versus enalapril alone in 20,702 hypertensive Chinese adults without folate fortification.
Key Findings
First stroke occurred in 2.7% of the folic acid group versus 3.4% of controls (HR 0.79) over 4.5 years.
Conclusions
Folic acid added to antihypertensive therapy reduced first stroke in a folate-deplete population.
Limitations
Findings may not generalize to folate-fortified populations; open questions on MTHFR subgroup effects.
Supplements Studied
First stroke occurred in 2.7% of participants receiving enalapril plus folic acid versus 3.4% receiving enalapril alone.
Related Health Concerns
Study Details
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