systematic_review
    2005

    Treatment of hyperlipoproteinemia with pantethine: a review and analysis of efficacy and tolerability

    McRae MP

    Published in Nutrition Research

    Methodology

    Pooled analysis of 28 trials with 646 participants receiving pantethine for hyperlipoproteinemia.

    Key Findings

    Average reductions of about 14% in total cholesterol, 20% in LDL and 33% in triglycerides, with HDL rising about 8%; tolerability was good.

    Conclusions

    Pantethine appears effective and well tolerated for dyslipidemia, though most included trials were old and small.

    Limitations

    Largely older, small, non-blinded Italian trials; high risk of publication bias.

    Supplements Studied

    Vitamin B5
    Vitamin

    Pantethine produced average reductions of about 14% in total cholesterol and 20% in LDL cholesterol across 28 trials.

    Outcomes Measured

    HDL Cholesterol Increase

    HDL cholesterol rose approximately 8% with pantethine treatment.

    Cholesterol Management
    Primary

    Pantethine reduced total cholesterol, LDL and triglycerides with an 8% rise in HDL.

    Related Health Concerns

    High Cholesterol (Dyslipidemia)

    Study Details

    Year:2005
    Sample Size:646
    Duration:16 weeks
    Quality Score:4/10

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