United States Pharmacopeia comprehensive safety review of Styphnolobium japonicum flower and flower bud
Madden E, McLachlan C, Oketch-Rabah H, Calderon AI
Published in Phytotherapy Research
Methodology
United States Pharmacopeia structured safety review of clinical, animal and case-report literature on Japanese Sophora flower and flower bud, a principal commercial source of rutin
Key Findings
No serious adverse events or toxicity were identified, though possible flavonoid drug interactions were noted and pregnancy data were absent.
Conclusions
Rutin from this source has a reassuring safety profile in typical supplement use, with pregnancy an explicit gap.
Limitations
Narrative safety review; limited long-term human data; no pregnancy data.
Supplements Studied
No serious adverse events or toxicity were reported in the clinical or experimental animal studies we reviewed.
Study Details
Access Study
Disclosures
Funding
United States Pharmacopeia
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.