Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis
Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, Reid IR
Published in BMJ
Abstract
Patient-level and trial-level meta-analysis of calcium supplements and cardiovascular events.
Key Findings
Calcium supplements without co-administered vitamin D were associated with an approximately 30% increased risk of myocardial infarction in pooled patient-level analysis.
Conclusions
A reassessment of the role of calcium supplements in osteoporosis management is warranted.
Limitations
Cardiovascular events were not primary endpoints; unblinded event ascertainment in some trials.
Supplements Studied
Calcium supplements without co-administered vitamin D were associated with an approximately 30% increased risk of myocardial infarction in pooled patient-level analysis.
Calcium supplements without co-administered vitamin D were associated with an approximately 30% increased risk of myocardial infarction in pooled patient-level analysis.
Outcomes Measured
Calcium supplements without co-administered vitamin D were associated with an approximately 30% increased risk of myocardial infarction in pooled patient-level analysis.
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.