The Essential Medicinal Chemistry of Curcumin
Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA
Published in Journal of Medicinal Chemistry
Methodology
Critical review of curcumin chemistry, assay interference, stability and pharmacokinetics across the preclinical and clinical literature.
Key Findings
Curcumin is chemically unstable, poorly absorbed and behaves as a pan-assay interference compound in many in vitro screens; no double-blind, placebo-controlled clinical trial of curcumin has been conclusively successful at that time.
Conclusions
Claims for curcumin should be interpreted cautiously; bioavailability-enhanced formulations and rigorous trials are required.
Limitations
Narrative critical review rather than quantitative synthesis; predates several newer formulation trials.
Supplements Studied
Related Health Concerns
Study Details
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Disclosures
Funding
US National Institutes of Health
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.