Growth Hormone Response to L-Arginine Alone and Combined with Different Doses of Growth Hormone-Releasing Hormone: A Systematic Review and Meta-Analysis
Goli P, Yazdi M, Heidari-Beni M, Kelishadi R
Published in International Journal of Endocrinology
Key Findings
Meta-analysis showed significant effects of L-arginine alone on growth hormone release, with larger responses when combined with GHRH; effect magnitude varied by dose and route.
Conclusions
L-arginine acutely stimulates GH secretion, mainly via somatostatin suppression.
Limitations
Pooled trials heterogeneous in dose, route (oral vs IV) and population; acute endocrine endpoints only.
Supplements Studied
Arginine (ARG) can modulate growth hormone (GH) release by suppressing its endogenous inhibitory regulator, somatostatin.
Outcomes Measured
Meta-analyses showed significant effects of ARG alone on GH rel[ease]
Study Details
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