Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag
Suhner A, Schlagenhauf P
Published in Chronobiology International
Methodology
Randomized double-blind trial comparing melatonin dosage forms (5 mg fast-release, 2 mg sustained-release, 0.5 mg fast-release) in air travellers crossing multiple time zones.
Key Findings
The 5 mg fast-release form gave the best subjective jet lag relief and sleep quality; sustained-release performed worst.
Conclusions
Melatonin formulation and timing determine jet lag benefit, with fast-release 5 mg most effective.
Limitations
Subjective diary outcomes; travellers self-managed timing; older trial.
Supplements Studied
Fast-release 5 mg melatonin gave the best subjective jet lag relief among dosage forms tested
Outcomes Measured
The 5 mg fast-release melatonin form gave the best subjective jet lag relief and sleep quality
Study Details
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