systematic_review
    2019

    Tauroursodeoxycholate-Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives

    Kusaczuk M

    Published in Cells

    Methodology

    Review of molecular mechanisms and therapeutic applications of TUDCA as a chemical chaperone

    Key Findings

    TUDCA reduces endoplasmic reticulum stress and apoptosis across hepatic, neuronal and metabolic models

    Conclusions

    TUDCA has broad chaperone-mediated activity with early-stage clinical potential

    Limitations

    Predominantly preclinical mechanistic evidence

    Supplements Studied

    TUDCA
    Compound

    TUDCA reduces endoplasmic reticulum stress and apoptosis across hepatic, neuronal and metabolic models

    Outcomes Measured

    Liver Protection

    TUDCA reduces endoplasmic reticulum stress and apoptosis in hepatic models

    Study Details

    Year:2019
    Quality Score:5/10

    Access Study

    View on DOIView on PubMedOriginal Source

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