Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease (VITAL)
Manson JE, Cook NR, Lee IM
Published in New England Journal of Medicine
Methodology
Nationwide randomized, placebo-controlled 2x2 factorial trial of vitamin D3 2000 IU/day.
Key Findings
Vitamin D3 did not reduce major cardiovascular events (HR 0.97) or invasive cancer versus placebo.
Conclusions
Vitamin D supplementation does not prevent cardiovascular disease in generally healthy adults.
Limitations
Largely vitamin D replete population; single dose tested.
Supplements Studied
Supplementation with vitamin D did not result in a lower incidence of major cardiovascular events than placebo.
Outcomes Measured
Supplementation with vitamin D did not result in a lower incidence of major cardiovascular events than placebo.
Supplementation with vitamin D did not result in a lower incidence of invasive cancer or cardiovascular events than placebo.
Vitamin D did not lower invasive cancer incidence, though secondary analyses suggested reduced cancer death with longer follow-up
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.