Emodin: A Review of Its Pharmacology, Toxicity and Pharmacokinetics
Dong X, Fu J, Yin X, Cao S, Li X, Lin L, Ni J
Published in Phytotherapy Research
Methodology
Review of preclinical pharmacology, toxicology and pharmacokinetic data for the anthraquinone emodin.
Key Findings
Emodin shows anticancer, anti-inflammatory, antimicrobial and hepatoprotective activity in vitro and in animals, but also demonstrates hepatotoxicity, nephrotoxicity and genotoxicity signals, with poor oral bioavailability.
Conclusions
Emodin has broad preclinical activity alongside meaningful toxicity signals; human clinical evidence is essentially absent.
Limitations
No human trials reviewed; heavy reliance on cell and rodent data.
Supplements Studied
Emodin demonstrates hepatotoxicity, nephrotoxicity and genotoxicity signals, with poor oral bioavailability.
Related Health Concerns
Study Details
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