Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S
Published in Clinical Interventions in Aging
Methodology
Multicenter, randomized, double-blind, non-inferiority trial of Curcuma domestica extract 1500 mg/day versus ibuprofen 1200 mg/day for 4 weeks in knee osteoarthritis.
Key Findings
Curcuma domestica extract was non-inferior to ibuprofen for pain, stiffness and function scores, and produced fewer abdominal pain/discomfort events.
Conclusions
Turmeric extract is as effective as ibuprofen for knee osteoarthritis over four weeks with better gastrointestinal tolerability.
Limitations
Short 4-week duration; no placebo arm; single-country population.
Supplements Studied
Curcuma domestica extract was non-inferior to ibuprofen for pain, stiffness and function, with fewer abdominal adverse events.
Outcomes Measured
Curcuma domestica extract was non-inferior to ibuprofen for joint pain, stiffness and function.
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Government Pharmaceutical Organization of Thailand
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.